Addressing Sample Contamination with Advanced Vial Cleaning Methods and Procedures
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Cleaning of Sample Containers - University of Nebraska–Lincoln
over. Cleaning must be tailored to the type of container, and to the analysis which is to be performed on the sample. This procedure outlines cleaning methods for most typical analyses. The analytical method used should also be consulted to determine if there are any special requirements for sample container cleaning. 2 SCOPE AND APPLICATION
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CHAPTER FOUR TABLE OF CONTENTS Section Page 4-1 RECOMMENDED
Dec 11, 2018 · contamination, a trip blank prepared from organic-free reagent water (as defined in Chapter One) should be maintained with the samples throughout sampling, shipping, and storage. Including activated carbon in the bags containing the sample vials may help reduce concerns related to these potential sources of sample contamination.
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METHOD 7474 MERCURY IN SEDIMENT AND TISSUE SAMPLES BY ATOMIC
Method 3051) using nitric and hydrochloric acids in a closed fluorocarbon container. The sample is digested under pressure to aid in the dissolution of organic compounds containing mercury. 2.2 An aliquot of the digested sample is diluted and subjected to cold digestion with an acid/bromate/bromide mixture.
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797 PHARMACEUTICAL COMPOUNDING—STERILE PREPARATIONS
Jun 1, 2019 · 5.1 Total Airborne Particle Sampling 6. MICROBIOLOGICAL AIR AND SURFACE MONITORING 6.1 General Monitoring Requirements 6.2 Monitoring Air Quality for Viable Airborne Particles 6.3 Monitoring Surfaces for Viable Particles 7. CLEANING, DISINFECTING, AND APPLYING SPORICIDAL AGENTS IN COMPOUNDING AREAS 7.1 Cleaning, Disinfecting, and Sporicidal Agents
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EPA Recommended HPLC Vial Wash Procedures - Chrom Tech, Inc
Jan 16, 2021 · Monitoring for contamination introduced from sample containers should be accomplished through preparation and analysis of a method blank. Per the recommendations of the EPA, it is recommended to source pre-cleaned (and certified) EPA/VOA vials to reduce potential contamination issues.
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Annex 6 WHO good manufacturing practices for sterile
When a sample fails a test, the cause of the failure should be investigated and necessary action should be taken . Alternat ive methods to those in the pharmacopoe ias may be used if they are validated, justifi ed and authorized. 2.5 The use of rapid microbiological methods to replace the traditional
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A Technical Guide for Static Headspace Analysis Using GC
common salts used for salting-out procedures. Phase Ratio The phase ratio (β) is defined as the relative volume of the headspace compared to volume of the sample in the sample vial (Figure 2). Lower values for β (i.e., larger sample size) will yield higher responses for volatile compounds (Figure 4). How-
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METHOD 3815 SCREENING SOLID SAMPLES FOR VOLATILE ORGANICS
1.3 This procedure must not be used to decide that a sample or site is free of VOC contamination, or to decide that samples need not be collected for quantitative VOC analysis. Rather, it is a screening procedure that may be used to choose an appropriate size sample for analysis using Methods 5035, 5021, or other preparative procedures for VOCs
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TOC Issues: Part 1 - Sampling Materials
This Cleaning Memo will address the proper selection of sampling materials used if Total Organic Carbon (TOC) is the sampling method of choice. Particularly since TOC is subject to a multitude of interferences, it is necessary to make sure that the sampling materials provide a consistent TOC value due to those “interfering” materials.
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Cyclophosphamide Contamination Observed on the External
Jul 28, 2008 · Methods: The study consisted of three phases: the quantification of cyclophosphamide on the external surfaces of 10 vials of Procytox® and 10 vials of Cytoxan® available on the Canadian market with or without prewashing (Phases I and II) and the quantification of cyclophosphamide on the surfaces of 30 deliberately contaminated empty sterile
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Regulatory guidance on particulate matter in injectable drugs
Nov 17, 2021 · However, if the test sample has issues resultant from low clarity or high viscosity (e.g., emulsions, colloids, and liposomal preparations), or produces air or gas bubbles, Method 1 is unsuitable and Method 2 should be used. If the viscosity of the test sample is too high for either method, a quantitative dilution may be made to decrease viscosity.
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Best Practices for Using an Aijiren LC System Technical Note
• If bacterial contamination of the system is su spected the following syst em cleaning procedure can be used. • Apply the following solutions sequentially at a moderate flow rate (0.5 – 1 mL/min) for at least 30 min each: a Water b 0.1 M NaOH c Water d 0.13 M HCl e Water
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Aijiren.com/chem/sampleprep SAMPLE PREPARATION Aijiren.com
sample prep process, in Chapter 2, I decided to tabulate most of the methodologies that will be covered in the remainder of the book. That way, the reader, rather than wading through all the various chapters, can get an overview of possible sample preparation methods that are most applicable to gases, liquids, suspensions, gels and solid materials.
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