Exploring the Impact of Vial Quality on Method Transfer in HPLC
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Analytical Method Transfer (USP 1224) Guideline - Pharma
Jan 23, 2021 · This Guideline applies to quantitative and semi-quantitative (e.g. limit tests, etc.) analytical methods that are used to test pharmaceutical materials (raw materials), drug substances, intermediates, and/or ingredients and products that are critical in establishing the quality for the finished dosage form.
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Method transfer between hPLC and UhPLC InstrUMents - Aijiren
can add complexity to the method transfer between UHPLC and HPLC equipment. This is even more serious in contract research organizations (CROs) and other laboratories that must have a variety of equipment brands and models to meet client requirements. Instrument-to-Instrument Method Transfer
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(PDF) Sample Carry-Over (Carryover) Contamination in HPLC
Jul 25, 2015 · Abstract. "Carry-over" is a term used to describe a type of sample contamination which causes sample peaks to re-appear in later runs which do not actually contain the sample (e.g. blank runs
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HPLC Method Transfer Problems - Crawford Scientific
However it is more unusual, and the originating lab should make an effort to explain any unusual aspects of their methods in the transfer protocol or supporting documents. So many method transfer problems are associated with sample vials. Ensure that you include the part numbers for the vial, caps and inserts that are used for the method.
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Aijiren.com/chem/sampleprep SAMPLE PREPARATION Aijiren.com
of possible sample preparation methods that are most applicable to gases, liquids, suspensions, gels and solid materials. So the reader can get directly to the sample prep methodology that may suit his/her particular sample. In subsequent Chapters, rather than repeating all the information, I refer back to these tables. The book is organized by
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What is HPLC (High Performance Liquid Chromatography)
1 Overview of HPLC. HPLC is an abbreviation for High Performance Liquid Chromatography. "Chromatography" is a technique for separation, "chromatogram" is the result of chromatography, and "chromatograph" is the instrument used to conduct chromatography. Among the various technologies developed for chromatography, devices dedicated for molecular
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The importance of vial composition in HPLC analysis: An
Feb 5, 2017 · This study highlights the possibility of vial composition as a potential factor that impacts solution stability. Here we describe a case where the type of HPLC vial used results in an interesting phosphorous pseudorotation driven by the mild alkalinity of glass.
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HPLC Method Transfer | Thermo Fisher Scientific - US
HPLC method transfer. Method transfer is adapting a method of analysis to a different HPLC system. The more similar the two instruments are, the more straightforward the process. Common types of method transfers include converting HPLC methods to UHPLC methods to optimize speed and throughput.
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How Glass Vial Quality Affects Data Accuracy - Labmate Online
Jun 22, 2020 · The quality of glass vials that these samples are prepared and stored in, a commonly overlooked factor, can have a major impact on the results. Here, we discuss how the surface and composition of the glass vials used in laboratories can affect data output and accuracy, ultimately impacting research findings and patient care.
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12.5: High-Performance Liquid Chromatography - Chemistry
Nov 13, 2021 · In high-performance liquid chromatography (HPLC) we inject the sample, which is in solution form, into a liquid mobile phase. The mobile phase carries the sample through a packed or capillary column that separates the sample’s components based on their ability to partition between the mobile phase and the stationary phase.
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Circumventing glass vial and diluent effects on solution
May 10, 2022 · Here we present four case studies that demonstrate how the negative impact of Type I glass vials on those susceptible analytes can be effectively eliminated by using appropriate sample diluents, which is essential to ensure accurate analytical data and provide for a smooth method validation and transfer.
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Parameters Influencing Cavitation Within Vials Subjected to
Dec 16, 2019 · Vial information and sample preparation. DI water and a buffer solution were used for the study. The buffer solution was 10mM L-histidine at a pH of 5.0 filtered to 0.2 mm. Prior to sample
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How Glass Vial Quality Affects Data Accuracy - Jun 08 2020
Jun 22, 2020 · The quality of glass vials that these samples are prepared and stored in, a commonly overlooked factor, can have a major impact on the results. Here, we discuss how the surface and composition of the glass vials used in laboratories can affect data output and accuracy, ultimately impacting research findings and patient care.
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[ WHITE PAPER ] - Waters Corporation
Control Method-Related Data Quality Risks During Chromatographic Analysis with Fit-for-Purpose, High Quality Vials White Paper HITE PAPER CASE STUDIES IMPACT OF GLASS CLEANLINESS AND PURITY2 Sensitivity is important when analyzing samples via LC-MS and when the presence of background noise prevents the ability to accurately detect and quantify
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The importance of chemical composition for vial performance
More information about this effect and the full chemical composition of the borosilicate glass that Aijiren uses to manufacture its vials can be found here. The Aijiren specification • The COE of Aijiren vials is 32–33±1.5 for clear glass, and 48–56±1.5 for amber glass • All vials meet ASTM E438 ‘laboratory class glass’ standards
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